The purpose of the study is to evaluate the effect of ALN-APP on measures of CAA disease
progression and to characterize the safety, tolerability, and pharmacodynamics (PD) of
ALN-APP in adult patients with sporadic CAA (sCAA) and Dutch-type CAA (D-CAA). The study
will be conducted over 2 periods: a 24-month double-blind treatment period and an
optional 18-month open-label extension (OLE) period. The estimated duration of study
participation, inclusive of screening, treatment, and additional safety follow-up, is up
to 50 months.

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy

Placebo

ALN-APP

Clinical Trial Site

A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Intrathecally Administered ALN-APP in Patients With Cerebral Amyloid Angiopathy (CAA)

Participants will be administered multiple doses of ALN-APP during the double-blind
treatment period and optional open-label extension period.

Participants will be administered multiple doses of placebo during the double-blind
treatment period. Participants who continue into the optional open-label extension period
will be administered multiple doses of ALN-APP.